{"product_id":"9780081000984","title":"A Practical Guide to Rational Drug Design","description":"\u003cp\u003eThis book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.\u003c\/p\u003e","brand":"Woodhead Publishing Ltd","offers":[{"title":"Default Title","offer_id":42517013790795,"sku":"00000_00000_00000_00000","price":7487.19,"currency_code":"THB","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0641\/0023\/7387\/files\/9780081000984-1.jpg?v=1783320730","url":"https:\/\/kinokuniya.co.th\/ja\/products\/9780081000984","provider":"Books Kinokuniya Thailand","version":"1.0","type":"link"}