Protease inhibitors (PIs), which are widely distributed in plants and animals and have a variety of functions, interfere with cancer development in a number of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. This volume contains 18 contributed chapters on aspects of both natural and synthetic PIs as chemopreventive agents. Annotation copyright Book News, Inc. Portland, Or.